Asymmetric Formal Synthesis of the Long-Acting DPP-4 Inhibitor Omarigliptin

A highly efficient asymmetric synthesis of the key tetrahydropyranol intermediate of DPP-4 inhibitor omarigliptin (1) is described. The successful development of a protecting-group- and precious-metal-free synthesis was achieved via the discovery of a practical asymmetric Henry reaction and the appl...

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Detalhes bibliográficos
Publicado no:J Org Chem
Main Authors: Peng, Feng, Chen, Yonggang, Chen, Cheng-yi, Dormer, Peter G., Kassim, Amude, McLaughlin, Mark, Reamer, Robert A., Sherer, Edward C., Song, Zhiguo J., Tan, Lushi, Tudge, Matthew T., Wan, Baoqiang, Chung, John Y. L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5933450/
https://ncbi.nlm.nih.gov/pubmed/28776371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.joc.7b01467
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