An efficient asymmetric synthesis of an estrogen receptor modulator by sulfoxide-directed borane reduction

An efficient asymmetric synthesis of a selective estrogen receptor modulator (SERM) that has a dihydrobenzoxathiin core structure bearing two stereogenic centers is reported. The stereogenic centers were established by an unprecedented chiral sulfoxide-directed stereospecific reduction of an α,β-uns...

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Autors principals: Song, Zhiguo J., King, Anthony O., Waters, Marjorie S., Lang, Fengrui, Zewge, Daniel, Bio, Matthew, Leazer, Johnnie L., Javadi, Gary, Kassim, Amude, Tschaen, David M., Reamer, Robert A., Rosner, Thorsten, Chilenski, Jennifer R., Mathre, David J., Volante, R. P., Tillyer, Richard
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2004
Matèries:
Asymmetric Catalysis Special Feature Part II
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC395984/
https://ncbi.nlm.nih.gov/pubmed/15079059
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0307415101
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