An efficient asymmetric synthesis of an estrogen receptor modulator by sulfoxide-directed borane reduction

An efficient asymmetric synthesis of a selective estrogen receptor modulator (SERM) that has a dihydrobenzoxathiin core structure bearing two stereogenic centers is reported. The stereogenic centers were established by an unprecedented chiral sulfoxide-directed stereospecific reduction of an α,β-uns...

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Autori principali: Song, Zhiguo J., King, Anthony O., Waters, Marjorie S., Lang, Fengrui, Zewge, Daniel, Bio, Matthew, Leazer, Johnnie L., Javadi, Gary, Kassim, Amude, Tschaen, David M., Reamer, Robert A., Rosner, Thorsten, Chilenski, Jennifer R., Mathre, David J., Volante, R. P., Tillyer, Richard
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2004
Soggetti:
Asymmetric Catalysis Special Feature Part II
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC395984/
https://ncbi.nlm.nih.gov/pubmed/15079059
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0307415101
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