BACE1 Mediates HIV-Associated and Excitotoxic Neuronal Damage Through an APP-Dependent Mechanism

HIV-associated neurocognitive disorders (HANDs) share common symptoms with Alzheimer's disease (AD), which is characterized by amyloid-β (Aβ) plaques. Plaques are formed by aggregation of Aβ oligomers, which may be the toxic species in AD pathogenesis, and oligomers are generated by cleavage of...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Stern, Anna L., Ghura, Shivesh, Gannon, Patrick J., Akay-Espinoza, Cagla, Phan, Jessica M., Yee, Alan C., Vassar, Robert, Gelman, Benjamin B., Kolson, Dennis L., Jordan-Sciutto, Kelly L.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2018
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5932640/
https://ncbi.nlm.nih.gov/pubmed/29632166
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1280-17.2018
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