Detection and Structural Characterization of Nucleophiles Trapped Reactive Metabolites of Limonin Using Liquid Chromatography-Mass Spectrometry

Limonin (LIM), a furan-containing limonoid, is one of the most abundant components of Dictamnus dasycarpus Turcz. Recent studies demonstrated that LIM has great potential for inhibiting the activity of drug-metabolizing enzymes. However, the mechanisms of LIM-induced enzyme inactivation processes re...

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Gepubliceerd in:J Anal Methods Chem
Hoofdauteurs: Deng, Yujie, Fu, Yudong, Xu, Shumin, Wang, Ping, Yang, Nailong, Li, Chengqian, Yu, Qing
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Hindawi 2018
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5932435/
https://ncbi.nlm.nih.gov/pubmed/29850372
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2018/3797389
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