Efficient Uptake of Recombinant Lipidated Survivin by Antigen-Presenting Cells Initiates Antigen Cross-Presentation and Antitumor Immunity

Survivin is overexpressed in various types of human cancer, but rarely expressed in terminally differentiated adult tissues. Thus, survivin is a potential target antigen for a cancer vaccine. However, self-tumor-associated antigens are not highly immunogenic. Bacteria-derived lipoproteins can activa...

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Detalles Bibliográficos
Publicado en:Front Immunol
Autores principales: Chiang, Chen-Yi, Chen, Yi-Jyun, Wu, Chiao-Chieh, Liu, Shih-Jen, Leng, Chih-Hsiang, Chen, Hsin-Wei
Formato: Artigo
Lenguaje:Inglês
Publicado: Frontiers Media S.A. 2018
Materias:
Immunology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5932405/
https://ncbi.nlm.nih.gov/pubmed/29755461
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.00822
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