Quantitative analysis of NAD synthesis-breakdown fluxes

The redox cofactor nicotinamide adenine dinucleotide (NAD) plays a central role in metabolism and is a substrate for signaling enzymes including poly-ADP-ribose-polymerases (PARPs) and sirtuins. NAD concentration falls during aging, which has triggered intense interest in strategies to boost NAD lev...

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Pubblicato in:Cell Metab
Autori principali: Liu, Ling, Su, Xiaoyang, Quinn, William J., Hui, Sheng, Krukenberg, Kristin, Frederick, David W., Redpath, Philip, Zhan, Le, Chellappa, Karthikeyani, White, Eileen, Migaud, Marie, Mitchison, Timothy J., Baur, Joseph A., Rabinowitz, Joshua D.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5932087/
https://ncbi.nlm.nih.gov/pubmed/29685734
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2018.03.018
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