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FTY720 Decreases Tumorigenesis in Group 3 Medulloblastoma Patient-Derived Xenografts

Group 3 tumors account for 28% of medulloblastomas and have the worst prognosis. FTY720, an immunosuppressant currently approved for treatment of multiple sclerosis, has shown antitumor effects in several human cancer cell lines. We hypothesized that treatment with FTY720 (fingolimod) would decrease...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Garner, Evan F., Williams, Adele P., Stafman, Laura L., Aye, Jamie M., Mroczek-Musulman, Elizabeth, Moore, Blake P., Stewart, Jerry E., Friedman, Gregory K., Beierle, Elizabeth A.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5932040/
https://ncbi.nlm.nih.gov/pubmed/29720672
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-25263-5
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