The Anti-microbial Peptide CRAMP Is Essential for Colon Homeostasis by Maintaining Microbiota Balance

Commensal bacteria are critical for physiological functions in the gut and dysbiosis in the gut may cause diseases. Here we report that mice deficient in cathelin-related antimicrobial peptide (CRAMP) were defective in the development of colon mucosa and highly sensitive to dextran-sulfate-sodium (D...

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Udgivet i:J Immunol
Main Authors: Yoshimura, Teizo, McLean, Mairi H., Dzutsev, Amiran K., Yao, Xiaohong, Chen, Keqiang, Huang, Jiaqiang, Gong, Wanghua, Zhou, Jiamin, Xiang, Yi, Badger, Jonathan, Ohuigin, Colm, Thovarai, Vishal, Tessarollo, Lino, Durum, Scott K., Trinchieri, Giorgio, Bian, Xiu-wu, Wang, Ji Ming
Format: Artigo
Sprog:Inglês
Udgivet: 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5931736/
https://ncbi.nlm.nih.gov/pubmed/29440355
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1602073
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