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FoxO restricts growth and differentiation of cells with elevated TORC1 activity under nutrient restriction
TORC1, a central regulator of cell survival, growth, and metabolism, is activated in a variety of cancers. Loss of the tumor suppressors PTEN and Tsc1/2 results in hyperactivation of TORC1. Tumors caused by the loss of PTEN, but not Tsc1/2, are often malignant and have been shown to be insensitive t...
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| Publicado no: | PLoS Genet |
|---|---|
| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5931687/ https://ncbi.nlm.nih.gov/pubmed/29677182 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1007347 |
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