Nutrient restriction enhances the proliferative potential of cells lacking the tumor suppressor PTEN in mitotic tissues

How single cells in a mitotic tissue progressively acquire hallmarks of cancer is poorly understood. We exploited mitotic recombination in developing Drosophila imaginal tissues to analyze the behavior of cells devoid of the tumor suppressor PTEN, a negative regulator of PI3K signaling, under varyin...

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Hlavní autoři: Nowak, Katarzyna, Seisenbacher, Gerhard, Hafen, Ernst, Stocker, Hugo
Médium: Artigo
Jazyk:Inglês
Vydáno: eLife Sciences Publications, Ltd 2013
Témata:
Cell Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3707060/
https://ncbi.nlm.nih.gov/pubmed/23853709
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.00380
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