Aldosterone Impairs Mitochondrial Function in Human Cardiac Fibroblasts via A-Kinase Anchor Protein 12

Aldosterone (Aldo) contributes to mitochondrial dysfunction and cardiac oxidative stress. Using a proteomic approach, A-kinase anchor protein (AKAP)-12 has been identified as a down-regulated protein by Aldo in human cardiac fibroblasts. We aim to characterize whether AKAP-12 down-regulation could b...

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Udgivet i:Sci Rep
Main Authors: Ibarrola, Jaime, Sadaba, Rafael, Martinez-Martinez, Ernesto, Garcia-Peña, Amaia, Arrieta, Vanessa, Alvarez, Virginia, Fernández-Celis, Amaya, Gainza, Alicia, Cachofeiro, Victoria, Santamaria, Enrique, Fernandez-Irigoyen, Joaquin, Jaisser, Frederic, Lopez-Andres, Natalia
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5931570/
https://ncbi.nlm.nih.gov/pubmed/29717226
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-25068-6
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