Beneficial Effects of Galectin-3 Blockade in Vascular and Aortic Valve Alterations in an Experimental Pressure Overload Model

Galectin-3 (Gal-3) is involved in cardiovascular fibrosis and aortic valve (AV) calcification. We hypothesized that Gal-3 pharmacological inhibition with modified citrus pectin (MCP) could reduce aortic and AV remodeling in normotensive rats with pressure overload (PO). Six weeks after aortic constr...

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Detalhes bibliográficos
Publicado no:Int J Mol Sci
Main Authors: Ibarrola, Jaime, Martínez-Martínez, Ernesto, Sádaba, J. Rafael, Arrieta, Vanessa, García-Peña, Amaia, Álvarez, Virginia, Fernández-Celis, Amaya, Gainza, Alicia, Rossignol, Patrick, Cachofeiro Ramos, Victoria, López-Andrés, Natalia
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5578054/
https://ncbi.nlm.nih.gov/pubmed/28758988
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms18081664
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