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Distinct mutational signatures characterize concurrent loss of polymerase proofreading and mismatch repair
Fidelity of DNA replication is maintained using polymerase proofreading and the mismatch repair pathway. Tumors with loss of function of either mechanism have elevated mutation rates with characteristic mutational signatures. Here we report that tumors with concurrent loss of both polymerase proofre...
Αποθηκεύτηκε σε:
| Τόπος έκδοσης: | Nat Commun |
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| Κύριοι συγγραφείς: | , , , , , , , , , , , |
| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
Nature Publishing Group UK
2018
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5931517/ https://ncbi.nlm.nih.gov/pubmed/29717118 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-04002-4 |
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