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Ciclopirox activates ATR-Chk1 signaling pathway leading to Cdc25A protein degradation
Ciclopirox olamine (CPX), an off-patent anti-fungal drug, has been found to inhibit the G(1)-cyclin dependent kinases partly by increasing the phosphorylation and degradation of Cdc25A. However, little is known about the molecular target(s) of CPX responsible for Cdc25A degradation. Here, we show th...
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| Publicado no: | Genes Cancer |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Impact Journals LLC
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5931253/ https://ncbi.nlm.nih.gov/pubmed/29725502 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/genesandcancer.166 |
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