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Hepatic thrombopoietin is required for bone marrow hematopoietic stem cell maintenance
Hematopoietic stem cell (HSC) maintenance depends on extrinsic cues. Currently, only local signals arising from the bone marrow niche have been shown to maintain HSCs. However, it is not known whether systemic factors also sustain HSCs. We assessed the physiological source of thrombopoietin (TPO), a...
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| Publicado no: | Science |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5930357/ https://ncbi.nlm.nih.gov/pubmed/29622652 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aap8861 |
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