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Dioxol and dihydrodioxin analogs of 2- and 3-phenylacetonitriles as potent anti-cancer agents with nanomolar activity against a variety of human cancer cells

A small library of (Z)-2-(benzo[d][1,3]dioxol-5-yl) and (Z)-2,3-dihydrobenzo [b][1,4] dioxin-6-yl analogs of 2- and 3-phenylacetonitriles has been synthesized and evaluated for their anti-cancer activities against a panel of 60 human cancer cell lines. The dihydrodioxin analog 3j and dioxol analogs...

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Bibliografiske detaljer
Udgivet i:Bioorg Med Chem Lett
Main Authors: Madadi, Nikhil R., Ketkar, Amit, Penthala, Narsimha R., Bostian, April C.L., Eoff, Robert L., Crooks, Peter A.
Format: Artigo
Sprog:Inglês
Udgivet: 2016
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5930014/
https://ncbi.nlm.nih.gov/pubmed/27017113
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2016.03.068
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