Enhancement of Cancer-Specific Protoporphyrin IX Fluorescence by Targeting Oncogenic Ras/MEK Pathway

Protoporphyrin IX (PpIX) is an endogenous fluorescent molecule that selectively accumulates in cancer cells treated with the heme precursor 5-aminolevulinic acid (5-ALA). This cancer-specific accumulation of PpIX is used to distinguish tumor from normal tissues in fluorescence-guided surgery (FGS) a...

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Veröffentlicht in:Theranostics
Hauptverfasser: Yoshioka, Ema, Chelakkot, Vipin Shankar, Licursi, Maria, Rutihinda, Suzette G, Som, Jayoti, Derwish, Leena, King, Justin J, Pongnopparat, Theerawat, Mearow, Karen, Larijani, Mani, Dorward, Ann M, Hirasawa, Kensuke
Format: Artigo
Sprache:Inglês
Veröffentlicht: Ivyspring International Publisher 2018
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5928876/
https://ncbi.nlm.nih.gov/pubmed/29721068
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/thno.22641
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