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IRF1 Downregulation by Ras/MEK Is Independent of Translational Control of IRF1 mRNA
Oncogenic activation of Ras/MEK downregulates the expression of interferon regulatory factor 1 (IRF1), which is a prerequisite for oncolytic viruses to replicate in cancer cells [1]. Moreover, restoration of IRF1 expression is essential to induce apoptosis of cancer cells treated with a MEK inhibito...
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| Publicado no: | PLoS One |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4980046/ https://ncbi.nlm.nih.gov/pubmed/27508303 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0160529 |
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