The Selective Antagonism of Adenosine A(2B) Receptors Reduces the Synaptic Failure and Neuronal Death Induced by Oxygen and Glucose Deprivation in Rat CA1 Hippocampus in Vitro

Ischemia is a multifactorial pathology characterized by different events evolving in time. Immediately after the ischemic insult, primary brain damage is due to the massive increase of extracellular glutamate. Adenosine in the brain increases dramatically during ischemia in concentrations able to st...

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Detalles Bibliográficos
Publicado en:Front Pharmacol
Autores principales: Fusco, Irene, Ugolini, Filippo, Lana, Daniele, Coppi, Elisabetta, Dettori, Ilaria, Gaviano, Lisa, Nosi, Daniele, Cherchi, Federica, Pedata, Felicita, Giovannini, Maria G., Pugliese, Anna M.
Formato: Artigo
Lenguaje:Inglês
Publicado: Frontiers Media S.A. 2018
Materias:
Pharmacology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5928446/
https://ncbi.nlm.nih.gov/pubmed/29740323
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2018.00399
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