The senescence-associated secretory phenotype is potentiated by feedforward regulatory mechanisms involving Zscan4 and TAK1

The senescence-associated secretory phenotype (SASP) can be provoked by side effects of therapeutic agents, fueling advanced complications including cancer resistance. However, the intracellular signal network supporting initiation and development of the SASP driven by treatment-induced damage remai...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Zhang, Boyi, Fu, Da, Xu, Qixia, Cong, Xianling, Wu, Chunyan, Zhong, Xiaoming, Ma, Yushui, Lv, Zhongwei, Chen, Fei, Han, Liu, Qian, Min, Chin, Y. Eugene, Lam, Eric W. -F., Chiao, Paul, Sun, Yu
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5928226/
https://ncbi.nlm.nih.gov/pubmed/29712904
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-04010-4
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