MSH6 haploinsufficiency at relapse contributes to the development of thiopurine resistance in pediatric B-lymphoblastic leukemia

Survival of children with relapsed acute lymphoblastic leukemia is poor, and understanding mechanisms underlying resistance is essential to developing new therapy. Relapse-specific heterozygous deletions in MSH6, a crucial part of DNA mismatch repair, are frequently detected. Our aim was to determin...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Τόπος έκδοσης:Haematologica
Κύριοι συγγραφείς: Evensen, Nikki A., Madhusoodhan, P. Pallavi, Meyer, Julia, Saliba, Jason, Chowdhury, Ashfiyah, Araten, David J., Nersting, Jacob, Bhatla, Teena, Vincent, Tiffaney L., Teachey, David, Hunger, Stephen P., Yang, Jun, Schmiegelow, Kjeld, Carroll, William L.
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: Ferrata Storti Foundation 2018
Θέματα:
Article
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5927991/
https://ncbi.nlm.nih.gov/pubmed/29449434
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2017.176362
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