MSH6 haploinsufficiency at relapse contributes to the development of thiopurine resistance in pediatric B-lymphoblastic leukemia

Survival of children with relapsed acute lymphoblastic leukemia is poor, and understanding mechanisms underlying resistance is essential to developing new therapy. Relapse-specific heterozygous deletions in MSH6, a crucial part of DNA mismatch repair, are frequently detected. Our aim was to determin...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:Haematologica
Main Authors: Evensen, Nikki A., Madhusoodhan, P. Pallavi, Meyer, Julia, Saliba, Jason, Chowdhury, Ashfiyah, Araten, David J., Nersting, Jacob, Bhatla, Teena, Vincent, Tiffaney L., Teachey, David, Hunger, Stephen P., Yang, Jun, Schmiegelow, Kjeld, Carroll, William L.
פורמט: Artigo
שפה:Inglês
יצא לאור: Ferrata Storti Foundation 2018
נושאים:
Article
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC5927991/
https://ncbi.nlm.nih.gov/pubmed/29449434
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2017.176362
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