Timing the Landmark Events in the Evolution of Clear Cell Renal Cell Cancer: TRACERx Renal

Clear cell renal cell carcinoma (ccRCC) is characterized by near-universal loss of the short arm of chromosome 3, deleting several tumor suppressor genes. We analyzed whole genomes from 95 biopsies across 33 patients with clear cell renal cell carcinoma. We find hotspots of point mutations in the 5′...

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Detalhes bibliográficos
Publicado no:Cell
Main Authors: Mitchell, Thomas J., Turajlic, Samra, Rowan, Andrew, Nicol, David, Farmery, James H.R., O’Brien, Tim, Martincorena, Inigo, Tarpey, Patrick, Angelopoulos, Nicos, Yates, Lucy R., Butler, Adam P., Raine, Keiran, Stewart, Grant D., Challacombe, Ben, Fernando, Archana, Lopez, Jose I., Hazell, Steve, Chandra, Ashish, Chowdhury, Simon, Rudman, Sarah, Soultati, Aspasia, Stamp, Gordon, Fotiadis, Nicos, Pickering, Lisa, Au, Lewis, Spain, Lavinia, Lynch, Joanna, Stares, Mark, Teague, Jon, Maura, Francesco, Wedge, David C., Horswell, Stuart, Chambers, Tim, Litchfield, Kevin, Xu, Hang, Stewart, Aengus, Elaidi, Reza, Oudard, Stéphane, McGranahan, Nicholas, Csabai, Istvan, Gore, Martin, Futreal, P. Andrew, Larkin, James, Lynch, Andy G., Szallasi, Zoltan, Swanton, Charles, Campbell, Peter J.
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5927631/
https://ncbi.nlm.nih.gov/pubmed/29656891
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2018.02.020
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