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Computational Analysis for the Rational Design of Anti-Amyloid Beta (Aβ) Antibodies
Alzheimer’s disease (AD) is a neurodegenerative disorder that lacks effective treatment options. Anti-amyloid beta (Aβ) antibodies are the leading drug candidates to treat AD, but the results of clinical trials have been disappointing. Introducing rational mutations into anti-Aβ antibodies to increa...
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| Published in: | J Phys Chem B |
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| Main Authors: | , , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
2018
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5927393/ https://ncbi.nlm.nih.gov/pubmed/29617557 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jpcb.8b01837 |
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