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A Radicicol Derivative, KF58333, Inhibits Expression of Hypoxia‐inducible Factor‐1α and Vascular Endothelial Growth Factor, Angiogenesis and Growth of Human Breast Cancer Xenografts

A novel oxime derivative of radicicol, KF58333, binds to the heat shock protein 90 (Hsp90) and destabilizes its associated signaling molecules. These effects play a critical role in the growth inhibition of tumor cells. To further investigate the effects of this agent, it was administered to two hum...

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Detalhes bibliográficos
Publicado no:Jpn J Cancer Res
Main Authors: Kurebayashi, Junichi, Otsuki, Takemi, Kurosumi, Masafumi, Soga, Shiro, Akinaga, Shiro, Sonoo, Hiroshi
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2001
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5926684/
https://ncbi.nlm.nih.gov/pubmed/11749701
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1349-7006.2001.tb02159.x
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