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Transduction of a Fiber‐mutant Adenovirus for the HSVtk Gene Highly Augments the Cytopathic Effect towards Gliomas

Suicide gene therapy utilizing the herpes simplex thymidine kinase (HSVtk)/ganciclovir (GCV) system has been performed to kill cancer cells. However, the low transduction efficiency of HSVtk gene into cancer cells critically limits its efficacy in cancer treatment in clinical situations. To improve...

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Detalhes bibliográficos
Publicado no:Jpn J Cancer Res
Main Authors: Shinoura, Nobusada, Sakurai, Shinya, Asai, Akio, Kirino, Takaaki, Hamada, Hirofumi
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2000
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5926260/
https://ncbi.nlm.nih.gov/pubmed/11050474
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1349-7006.2000.tb00881.x
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