Adenovirus‐mediated Gene Transduction of IkB or IkB Plus Bax Gene Drastically Enhances Tumor Necrosis Factor (TNF)‐induced Apoptosis in Human Gliomas

Tumor necrosis factor‐α (TNF), which was initially supposed to be a promising cancer therapeutic reagent, does not kill most types of cancer cells partly due to the activation of an anti‐apoptotic gene, NF‐kB. NF‐kB forms an inactive complex with the inhibitor kappa B alpha (IkBα), which is rapidly...

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Pubblicato in:Jpn J Cancer Res
Autori principali: Shinoura, Nobusada, Yamamoto, Naoki, Yoshida, Yoko, Fujita, Takashi, Saito, Nobuto, Asai, Akio, Kirino, Takaaki, Hamada, Hirofumi
Natura: Artigo
Lingua:Inglês
Pubblicazione: Blackwell Publishing Ltd 2000
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5926230/
https://ncbi.nlm.nih.gov/pubmed/10744043
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1349-7006.2000.tb00858.x
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