Genome-wide CRISPR screen identifies FAM49B as a key regulator of actin dynamics and T cell activation

Despite decades of research, mechanisms controlling T cell activation remain only partially understood, which hampers T cell-based immune cancer therapies. Here, we performed a genome-wide CRISPR screen to search for genes that regulate T cell activation. Our screen confirmed many of the known regul...

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Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Main Authors: Shang, Wanjing, Jiang, Yong, Boettcher, Michael, Ding, Kang, Mollenauer, Marianne, Liu, Zhongyi, Wen, Xiaofeng, Liu, Chang, Hao, Piliang, Zhao, Suwen, McManus, Michael T., Wei, Lai, Weiss, Arthur, Wang, Haopeng
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2018
Assuntos:
PNAS Plus
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5924929/
https://ncbi.nlm.nih.gov/pubmed/29632189
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1801340115
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