Macrophages impede CD8 T cells from reaching tumor cells and limit the efficacy of anti–PD-1 treatment

In a large proportion of cancer patients, CD8 T cells are excluded from the vicinity of cancer cells. The inability of CD8 T cells to reach tumor cells is considered an important mechanism of resistance to cancer immunotherapy. We show that, in human lung squamous-cell carcinomas, exclusion of CD8 T...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Peranzoni, Elisa, Lemoine, Jean, Vimeux, Lene, Feuillet, Vincent, Barrin, Sarah, Kantari-Mimoun, Chahrazade, Bercovici, Nadège, Guérin, Marion, Biton, Jérôme, Ouakrim, Hanane, Régnier, Fabienne, Lupo, Audrey, Alifano, Marco, Damotte, Diane, Donnadieu, Emmanuel
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2018
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PNAS Plus
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5924916/
https://ncbi.nlm.nih.gov/pubmed/29632196
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1720948115
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