TGFβ blocks IFNα/β release and tumor rejection in spontaneous mammary tumors

Type I interferons (IFN) are being rediscovered as potent anti-tumoral agents. Activation of the STimulator of INterferon Genes (STING) by DMXAA (5,6-dimethylxanthenone-4-acetic acid) can induce strong production of IFNα/β and rejection of transplanted primary tumors. In the present study, we addres...

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發表在:Nat Commun
Main Authors: Guerin, Marion V., Regnier, Fabienne, Feuillet, Vincent, Vimeux, Lene, Weiss, Julia M., Bismuth, Georges, Altan-Bonnet, Gregoire, Guilbert, Thomas, Thoreau, Maxime, Finisguerra, Veronica, Donnadieu, Emmanuel, Trautmann, Alain, Bercovici, Nadège
格式: Artigo
語言:Inglês
出版: Nature Publishing Group UK 2019
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6739328/
https://ncbi.nlm.nih.gov/pubmed/31511510
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-11998-w
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