HPV-16 E7 expression up-regulates phospholipase D activity and promotes rapamycin resistance in a pRB-dependent manner

BACKGROUND: Human Papillomavirus (HPV) infection is the main risk factor for the development and progression of cervical cancer. HPV-16 E6 and E7 expression is essential for induction and maintenance of the transformed phenotype. These oncoproteins interfere with the function of several intracellula...

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Vydáno v:BMC Cancer
Hlavní autoři: Rabachini, Tatiana, Boccardo, Enrique, Andrade, Rubiana, Perez, Katia Regina, Nonogaki, Suely, Cuccovia, Iolanda Midea, Villa, Luisa Lina
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2018
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5923196/
https://ncbi.nlm.nih.gov/pubmed/29703186
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-018-4392-8
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