A New Marker of Echinocandin Activity in an In Vitro Pharmacokinetic/Pharmacodynamic Model Correlates with an Animal Model of Aspergillus fumigatus Infection

The lack of a quantifiable marker for echinocandin activity hinders in vitro pharmacokinetic/pharmacodynamic (PK/PD) studies for Aspergillus spp. We developed an in vitro PK/PD model simulating the pharmacokinetics of anidulafungin and assessing its pharmacodynamics against Aspergillus fumigatus wit...

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Publicado en:Antimicrob Agents Chemother
Autores principales: Meletiadis, Joseph, Siopi, Maria, Tsakris, Athanassios, Mouton, Johan W., Pournaras, Spyros
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2018
Materias:
Susceptibility
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5923178/
https://ncbi.nlm.nih.gov/pubmed/29463527
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02322-17
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