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Constitutive Activation of MexT by Amino Acid Substitutions Results in MexEF-OprN Overproduction in Clinical Isolates of Pseudomonas aeruginosa

When overproduced, the multidrug efflux system MexEF-OprN increases the resistance of Pseudomonas aeruginosa to fluoroquinolones, chloramphenicol, and trimethoprim. In this work, we demonstrate that gain-of-function mutations in the regulatory gene mexT result in oligomerization of the LysR regulato...

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書誌詳細
出版年:Antimicrob Agents Chemother
主要な著者: Juarez, Paulo, Broutin, Isabelle, Bordi, Christophe, Plésiat, Patrick, Llanes, Catherine
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Microbiology 2018
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5923100/
https://ncbi.nlm.nih.gov/pubmed/29530852
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02445-17
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