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Evidence of MexT-Independent Overexpression of MexEF-OprN Multidrug Efflux Pump of Pseudomonas aeruginosa in Presence of Metabolic Stress

BACKGROUND: The Pseudomonas aeruginosa MexEF-OprN efflux pump confers resistance to clinically significant antibiotics. Regulation of mexEF-oprN operon expression is multifaceted with the MexT activator being one of the most prominent regulatory proteins. METHODOLOGY: We have exploited the impaired...

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Autors principals: Kumar, Ayush, Schweizer, Herbert P.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2011
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3200333/
https://ncbi.nlm.nih.gov/pubmed/22039504
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0026520
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