Peripheral tissues reprogram CD8(+) T cells for pathogenicity during graft-versus-host disease

Graft-versus-host disease (GVHD) is a life-threatening complication of allogeneic stem cell transplantation induced by the influx of donor-derived effector T cells (T(E)) into peripheral tissues. Current treatment strategies rely on targeting systemic T cells; however, the precise location and natur...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Santos e Sousa, Pedro, Ciré, Séverine, Conlan, Thomas, Jardine, Laura, Tkacz, Claire, Ferrer, Ivana R., Lomas, Cara, Ward, Sophie, West, Heather, Dertschnig, Simone, Blobner, Sven, Means, Terry K., Henderson, Stephen, Kaplan, Daniel H., Collin, Matthew, Plagnol, Vincent, Bennett, Clare L., Chakraverty, Ronjon
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5922296/
https://ncbi.nlm.nih.gov/pubmed/29515032
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.97011
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