Massive aggrecan and versican accumulation in thoracic aortic aneurysm and dissection

Proteoglycan accumulation is a hallmark of medial degeneration in thoracic aortic aneurysm and dissection (TAAD). Here, we defined the aortic proteoglycanome using mass spectrometry, and based on the findings, investigated the large aggregating proteoglycans aggrecan and versican in human ascending...

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發表在:JCI Insight
Main Authors: Cikach, Frank S., Koch, Christopher D., Mead, Timothy J., Galatioto, Josephine, Willard, Belinda B., Emerton, Kelly B., Eagleton, Matthew J., Blackstone, Eugene H., Ramirez, Francesco, Roselli, Eric E., Apte, Suneel S.
格式: Artigo
語言:Inglês
出版: American Society for Clinical Investigation 2018
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Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5922288/
https://ncbi.nlm.nih.gov/pubmed/29515038
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.97167
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