Massive aggrecan and versican accumulation in thoracic aortic aneurysm and dissection

Proteoglycan accumulation is a hallmark of medial degeneration in thoracic aortic aneurysm and dissection (TAAD). Here, we defined the aortic proteoglycanome using mass spectrometry, and based on the findings, investigated the large aggregating proteoglycans aggrecan and versican in human ascending...

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Publicado en:JCI Insight
Autores principales: Cikach, Frank S., Koch, Christopher D., Mead, Timothy J., Galatioto, Josephine, Willard, Belinda B., Emerton, Kelly B., Eagleton, Matthew J., Blackstone, Eugene H., Ramirez, Francesco, Roselli, Eric E., Apte, Suneel S.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Clinical Investigation 2018
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5922288/
https://ncbi.nlm.nih.gov/pubmed/29515038
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.97167
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