Massive aggrecan and versican accumulation in thoracic aortic aneurysm and dissection

Proteoglycan accumulation is a hallmark of medial degeneration in thoracic aortic aneurysm and dissection (TAAD). Here, we defined the aortic proteoglycanome using mass spectrometry, and based on the findings, investigated the large aggregating proteoglycans aggrecan and versican in human ascending...

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Publicat a:JCI Insight
Autors principals: Cikach, Frank S., Koch, Christopher D., Mead, Timothy J., Galatioto, Josephine, Willard, Belinda B., Emerton, Kelly B., Eagleton, Matthew J., Blackstone, Eugene H., Ramirez, Francesco, Roselli, Eric E., Apte, Suneel S.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2018
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5922288/
https://ncbi.nlm.nih.gov/pubmed/29515038
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.97167
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