Versican Proteolysis by ADAMTS Proteases and Its Influence on Sex Steroid Receptor Expression in Uterine Leiomyoma

CONTEXT: Leiomyomas have abundant extracellular matrix (ECM), with upregulation of versican, a large proteoglycan. OBJECTIVE: We investigated ADAMTS (a disintegrin-like and metalloprotease with thrombospondin type 1 motifs) protease-mediated versican cleavage in myometrium and leiomyoma and the effe...

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Foilsithe in:J Clin Endocrinol Metab
Main Authors: Gueye, Ndeye-Aicha, Mead, Timothy J., Koch, Christopher D., Biscotti, Charles V., Falcone, Tommaso, Apte, Suneel S.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Endocrine Society 2017
Ábhair:
Clinical Research Articles
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5443325/
https://ncbi.nlm.nih.gov/pubmed/28323982
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/jc.2016-3527
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