Interferon-γ converts human microvascular pericytes into negative regulators of alloimmunity through induction of indoleamine 2,3-dioxygenase 1

Early acute rejection of human allografts is mediated by circulating alloreactive host effector memory T cells (T(EM)). T(EM) infiltration typically occurs across graft postcapillary venules and involves sequential interactions with graft-derived endothelial cells (ECs) and pericytes (PCs). While th...

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Bibliographic Details
Published in:JCI Insight
Main Authors: Liu, Rebecca, Merola, Jonathan, Manes, Thomas D., Qin, Lingfeng, Tietjen, Gregory T., López-Giráldez, Francesc, Broecker, Verena, Fang, Caodi, Xie, Catherine, Chen, Ping-Min, Kirkiles-Smith, Nancy C., Jane-Wit, Dan, Pober, Jordan S.
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 2018
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5922286/
https://ncbi.nlm.nih.gov/pubmed/29515027
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.97881
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