Nlrp3-dependent IL-1β inhibits CD103(+) dendritic cell differentiation in the gut

Inflammatory bowel disease (IBD) is associated with enhanced levels of the IL-1 family cytokines IL-1β and IL-18, which are activated by the Nlrp3 inflammasome. Here, we investigated the role of inflammasome-driven cytokine release on T cell polarization and DC differentiation in steady state and T...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Mak’Anyengo, Rachel, Duewell, Peter, Reichl, Cornelia, Hörth, Christine, Lehr, Hans‑Anton, Fischer, Sandra, Clavel, Thomas, Denk, Gerald, Hohenester, Simon, Kobold, Sebastian, Endres, Stefan, Schnurr, Max, Bauer, Christian
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5922280/
https://ncbi.nlm.nih.gov/pubmed/29515025
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.96322
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