Significant Correlation of Nitric Oxide Synthase Activity and p53 Gene Mutation in Stage I Lung Adenocarcinoma

Nitric oxide (NO) and its derivatives can directly cause DNA damage and mutation in vitro and may play a role in the multistage carcinogenic process. It has been reported that NO induces mutation in the p53 tumor suppressor gene; we therefore analyzed the relationship between NO synthase 9 activity...

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Detalhes bibliográficos
Publicado no:Jpn J Cancer Res
Main Authors: Fujimoto, Hisao, Sasaki, Ji‐ichiro, Matsumoto, Mitsuhiro, Suga, Moritaka, Ando, Yukio, Iggo, Richard, Tada, Mitsuhiro, Saya, Hideyuki, Ando, Masayuki
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 1998
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5921893/
https://ncbi.nlm.nih.gov/pubmed/9738975
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1349-7006.1998.tb03273.x
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