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Nitric Oxide Generation from Hydroxyurea via Copper‐catalyzed Peroxidation and Implications for Pharmacological Actions of Hydroxyurea
We investigated the generation of nitric oxide (NO) by H(2)O(2)dependent peroxidation of hydroxyurea in the presence of copper‐containing proteins such as Cu, Zn‐snperoxide dismutase (Cu, Zn‐SOD) or ceruloplasmin as a catalyst. In the reaction mixture of hydroxyurea, Cu, Zn‐SOD, and H(2)O(2), “NO ge...
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| Publicado no: | Jpn J Cancer Res |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Blackwell Publishing Ltd
1997
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5921347/ https://ncbi.nlm.nih.gov/pubmed/9473738 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1349-7006.1997.tb00349.x |
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