Effect of Glutathione Depletion on Cisplatin Resistance in Cancer Cells Transfected with the γ‐Glutamylcysteine Synthetase Gene

Overexpression of the human γ‐glutamylcysteine synthetase (γ‐GCS) gene resulted in cisplatin resistance with an increased glutathione (GSH) content, increased ATP‐dependent glutatbione S‐conjugate export pump (GS‐X pump) activity and decreased platinum accumulation in human lung cancer cells transfe...

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Vydáno v:Jpn J Cancer Res
Hlavní autoři: Kurokawa, Hirokazu, Nishio, Kazuto, Ishida, Tomoyuki, Arioka, Hitoshi, Fukuoka, Kazuya, Nomoto, Taisuke, Fukumoto, Hisao, Yokote, Hideyuki, Saijo, Nagahiro
Médium: Artigo
Jazyk:Inglês
Vydáno: Blackwell Publishing Ltd 1997
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5921367/
https://ncbi.nlm.nih.gov/pubmed/9119737
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1349-7006.1997.tb00354.x
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