Inhibitory Effect of NS‐398, a Selective Cyclooxygenase‐2 Inhibitor, on Azoxymethane‐induced Aberrant Crypt Foci in Colon Carcinogenesis of F344 Rats

Prostaglandin E(2), which is produced by cyclooxygenase (COX) during arachidonic acid metabolism, is considered to be related to colon Carcinogenesis. Therefore, the effect of NS‐398 (N‐(2‐cyclohexyl‐oxy‐4‐nitrophenyl)methanesulfonamide), a COX‐2 inhibitor, was examined in azoxymethane (AOM)‐induced...

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Publicat a:Jpn J Cancer Res
Autors principals: Yoshimi, Naoki, Kawabata, Kunihiro, Hara, Akira, Matsunaga, Kengo, Yamada, Yasuhiro, Mori, Hideki
Format: Artigo
Idioma:Inglês
Publicat: Blackwell Publishing Ltd 1997
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5921322/
https://ncbi.nlm.nih.gov/pubmed/9439679
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1349-7006.1997.tb00328.x
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