Inhibitory Effect of NS‐398, a Selective Cyclooxygenase‐2 Inhibitor, on Azoxymethane‐induced Aberrant Crypt Foci in Colon Carcinogenesis of F344 Rats

Prostaglandin E(2), which is produced by cyclooxygenase (COX) during arachidonic acid metabolism, is considered to be related to colon Carcinogenesis. Therefore, the effect of NS‐398 (N‐(2‐cyclohexyl‐oxy‐4‐nitrophenyl)methanesulfonamide), a COX‐2 inhibitor, was examined in azoxymethane (AOM)‐induced...

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Detalhes bibliográficos
Publicado no:Jpn J Cancer Res
Main Authors: Yoshimi, Naoki, Kawabata, Kunihiro, Hara, Akira, Matsunaga, Kengo, Yamada, Yasuhiro, Mori, Hideki
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 1997
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5921322/
https://ncbi.nlm.nih.gov/pubmed/9439679
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1349-7006.1997.tb00328.x
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