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Biological Activity and Intracellular Metabolism of ZD1694 in Human Leukemia Cell Lines with Different Resistance Mechanisms to Antifolate Drugs
The biological activity and cellular metabolism of ZD1694, a novel folate‐based thymidylate synthase (TS) inhibitor, were analyzed in a human leukemia cell line, MOLT‐3, and its antifolate‐resistant sublines with different mechanisms of resistance to methotrexate (MTX), trimetrexate (TMQ) and N(10)‐...
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| Udgivet i: | Jpn J Cancer Res |
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| Main Authors: | , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Blackwell Publishing Ltd
1996
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5921156/ https://ncbi.nlm.nih.gov/pubmed/8698629 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1349-7006.1996.tb00291.x |
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