Dose‐dependent Induction of 8‐Hydroxyguanine and Preneoplastic Foci in Rat Liver by a Food‐derived Carcinogen, 2‐Amino‐3,8‐dimethylimidazo[4,5‐f]quinoxaline, at Low Dose Levels

Male F344 rats were administered 2‐amino‐3,8‐dimethylimidazo[4,5‐f]quinoxaline (MeIQx) in the diet at doses of 200, 50, 12.5, 3.2, 0.8, 0.2 and 0.05 ppm for 6 weeks, and partially hepatectomized 1 week after the beginning of MeIQx administration. Quantitative values for glutathione S‐transferase pla...

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Veröffentlicht in:Jpn J Cancer Res
Hauptverfasser: Kato, Toshio, Hasegawa, Ryohei, Nakae, Dai, Hirose, Masao, Yaono, Makoto, Cui, Lin, Kobayashi, Yozo, Konishi, Yoichi, Ito, Nobuyuki, Shirai, Tomoyuki
Format: Artigo
Sprache:Inglês
Veröffentlicht: Blackwell Publishing Ltd 1996
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5921060/
https://ncbi.nlm.nih.gov/pubmed/8609060
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1349-7006.1996.tb03149.x
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