Lack of Hepatocarcinogenicity of Combinations of Low Doses of 2-amino-3, 8-dimethylimidazo[4,5- f ]quinoxaline and Diethylnitrosamine in Rats: Indication for the Existence of a Threshold for Genotoxic Carcinogens

The purposes of the present study were to evaluate the hepatocarcinogenicity of concurrent treatment of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) and diethylnitrosamine (DEN) in rats and to determine whether no effect levels of combinations of these two different structural categories of...

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Detalhes bibliográficos
Main Authors: Wei, Min, Kakehashi, Anna, Yamano, Shotaro, Tamano, Seiko, Shirai, Tomoyuki, Wanibuchi, Hideki, Fukushima, Shoji
Formato: Artigo
Idioma:Inglês
Publicado em: Japanese Society of Toxicologic Pathology 2012
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3434336/
https://ncbi.nlm.nih.gov/pubmed/22988339
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1293/tox.25.209
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