載入...
Esterase-Catalyzed Siderophore Hydrolysis Activates an Enterobactin–Ciprofloxacin Conjugate and Confers Targeted Antibacterial Activity
Enteric Gram-negative bacteria, including Escherichia coli, biosynthesize and deploy the triscatecholate siderophore enterobactin (Ent) in the vertebrate host to acquire iron, an essential nutrient. We report that Ent–Cipro, a synthetic siderophore–antibiotic conjugate based on the native Ent platfo...
Na minha lista:
| 發表在: | J Am Chem Soc |
|---|---|
| Main Authors: | , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2018
|
| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5921047/ https://ncbi.nlm.nih.gov/pubmed/29578687 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.8b01042 |
| 標簽: |
添加標簽
沒有標簽, 成為第一個標記此記錄!
|